Kurse sind 15 Minuten zeitverzögert Realtimekurse aktivieren. Ved at bruge vores tjenester, accepterer du vores brug af cookies. Trading Our websites for market participants Cash market: Trading Charity at the Frankfurt Stock Exchange brings ,
Andrea Rolvering most warmly for her development work and support after the IPO. Her expertise and her network in the area of investor relations were a great asset for our company in establishing our investor relations structures. We wish her all the best for her private and professional future. At the same time, we are pleased that Dafne Sanac is taking over the task and the future communication with our investors and analysts. She also gained previous experience in auditing, consulting and banking.
In , Italian lifestyle brand Vapiano created a new category in system gastronomy with its innovative "fresh casual dining" concept combining elements from "fast casual" and "casual dining".
The restaurant concept is based on quality, uncompromisingly fresh ingredients, and transparency. Pasta, pizza dough, sauces, dressings and desserts are handmade each day in every Vapiano.
The recipe for success also includes the cosmopolitan ambiance. Long oak tables invite communication, a fully grown olive tree and a cozy bar and lounge area characterize the feel-good atmosphere found in every Vapiano. Vapiano also represents autonomy and individuality, so guests can choose between different "Guest Journeys".
Guests decide whether they will order their food from the Vapianisti, at the terminal or via the Vapiano app, and whether they will pay via chip card or app. Kundeservice Om Nordnet Bliv kunde Log ind. BGBIO , announces that the first patient has been dosed in an investigator-initiated phase II trial of bemcentinib, a selective, potent and orally bio-available AXL inhibitor, in patients with high-risk myelodysplastic syndrome MDS who have failed first-line treatment with hypomethylating agents.
The trial may also enrol a proportion of patients with acute myeloid leukaemia AML. The study will allow for the evaluation of potential predictive and pharmacodynamic biomarkers for MDS in bone marrow and blood, including those associated with patient benefit from bemcentinib. The survival is still dismal, especially in elderly patients who are not eligible for allogeneic stem cell transplantation and who have failed first line treatment with hypomethylating agents.
Pre-clinical studies with the inhibitor bemcentinib demonstrated in vitro and in mouse models that leukaemic proliferation was blocked by interference with AXL signalling. We are very pleased that Prof. Platzbecker and GWT-TUD are initiating this study, which if positive will add valuable information on bemcentinibs monotherapy use in a larger leukaemia population and provide support for our broader development plans for bemcentinib in these indications.
We look forward to reporting results as the trial progresses. Drugs that modify immunological responses can improve blood values and prolong survival in some patients.
Thus far, however, the only curative treatment for MDS remains stem cell transplantation. Hence, there is an urgent need for novel therapies to treat MDS.
About AXL AXL kinase is a cell membrane receptor and an essential mediator of the biological mechanisms underlying aggressive and life-threatening diseases.
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